Summary


Graphene is deemed the most promising, versatile, economic and sustainable key enabling nanotechnologies, addressing the Horizon 2020 objectives to apply technological innovation and economic exploitation to the current societal and industrial challenges.

Due to unconventional properties, graphene may potentially bring innovative solutions in a wide range of applications. Besides materials science, it also offers new fascinating perspectives in nanomedicine for the development of new therapeutics delivery approaches, imaging as well as biosensor-based diagnostic tools.

However, still limited amount of results are available on the biological responses and the possible toxic effects of graphene and derived materials. The potential nano-interactions with biological systems deriving from the physico-chemical properties and reactivity of these materials are raising public concern on risks for human health and environment.

Independently from any specific purpose, a critical step for any translational application is represented by the assessment of graphene safety and impact on the immune system. Following any type of exposures, nanomaterials immediately contact the organism immune cells. Hence the investigation of the immune cell reactions induced by graphene is a milestone for the safe exploitation of this material for therapeutic and diagnostic applications.

G-IMMUNOMICS overall objective is to provide new insights on the safety and immune impact of several types of graphene on different cell types and organisms using an unexplored approach based on proteomics and genomics. The project mission is to lay the basis for a safe graphene technology exploitation by defining the key features of highly bio and immune-compatible materials.

The structure of the G-IMMUNOMICS work plan adheres to the project overall vision, thus making sure that the scientific and adopted technical methodology will sufficiently result in specific tangible achievements in relation to the scientific objectives.